Iron Man has been brought to console with some success by Sega, and has steadily moved up the charts since its release - claiming fifth spot in the ChartTrack/ELSPA All Formats rankings in the UK last week.
According to the BBC, The Chronicles of Narnia: Prince Caspian took $56.6m (£29m) between Friday and Sunday at US cinemas to bump Iron Man off the top spot after two weeks.
The Disney game is due for release on 360, PS3, PS3, Wii, PC, DS and PS2 on June 9th in Europe.
Iron Man took $31.2 million (£15m) in the period.
Romantic comedy What Happens in Vegas, starring Cameron Diaz, took $13.9m (£7.1m) to hit the third spot.
Speed Racer – which has been brought to console by Warner Bros – was fourth, taking $7.6m (£3.9m) in its second week.
Jeff Goldstein of the film's studio Warner Bros' said next weekend - which is Memorial Weekend in the US - was "do or die" for the movie, which cost $120m (£61m) to make.
The eagerly-anticipated Indiana Jones and the Kingdom of the Crystal Skull, which had its premiere at the Cannes Film Festival on Sunday, will open in cinemas in the US and Canada on Thursday.