Capcom's Street Fighter X Tekken and Asura's Wrath will not be available from GAME or Gamestation.
Both were scheduled for release this Friday on March 9th.
It is the latest in a string of blockbusters not stocked by the High Street chain, including Mass Effect 3, Mario Party 9, The Last Story and FIFA Street.
GAME has lost credit insurance with suppliers following a poor Christmas.
It has been given some support by its banks, but has had to negotiate better credit deals with its suppliers.
The company has failed to secure better terms with Nintendo, EA and now Capcom.
Both Street Fighter and Asura's Wrath will be available at HMV, Play.com, Amazon.co.uk, Shopto.net, The Hut, leading independent retailers and supermarkets.
No decision has yet been made on Resident Evil: Operation Raccoon City, which launches on March 23rd.
"Unfortunately Capcom must confirm that Street Fighter x Tekken for PlayStation 3 and Xbox 360 and Asura’s Wrath, both scheduled for release on Friday March 9, will not be stocked by GAME or gamestation either in their retail outlets or on their online stores operating in the UK and Ireland," a Capcom spokesperson told MCV.
"Capcom wants to reassure its consumers that both these titles, including the Special Edition of Street Fighter X Tekken, will be available at a wide variety of retailers across the UK and Ireland. For those consumers who have already placed a deposit for a pre-order for any of these titles then a full refund will be available – please contact your local GAME or Gamestation shop or visit the online stores."