The title won trophies for Best Technology and Best Visual Art, as well as Best Game at the event, held as part of the Games Developers Conference in San Francisco.
Capcom’s Okami and Nintendo’s Wii Sports were the other big winners, with two awards each. Both titles collected a prize in the Innovation category, with Okami also picking up a gong for Character Design and Wii Sports triumphing the Game Design category.
Guitar Hero 2 picked up the trophy for best audio – following on from the original Guitar Hero's win in the category last year – and Legend of Zelda: Twilight Princess won for Best Writing.
Creator of THQ’s Titan Quest Iron Lore Entertainment was recognised as Best New Studio.
Nintendo’s Shigeru Miyamoto was singled out for a Lifetime Achievement award.