A sequel to recent 3DS release Kid Icarus: Uprising looks incredibly unlikely.
The 3DS game itself is 25 years in the making, with the original release of the NES game dating back to December 1986.
However, after a prolonged development period for Uprising – which was initially presumed to be a 3DS launch title – then game's lead developer Masahiro Sakurai has told IGN that a sequel is unlikely.
If by ‘lasting universe' you mean to ask if there's a sequel, the answer is no,” he confirmed.
[This is] because we pushed a lot into the game in order to let people have this short yet deep experience, but the novelty of that would likely grow thin in the next game. For now, my thought is that perhaps we'll see someone else besides me make another Kid Icarus in another 25 years.”