UFC 2009: Undisputed is this weeks' surprise No. 1, grappling the top spot from Nintendo's ever-present Wii Fit.
The THQ-published brawler is part of an all-new Top 3, which includes Pokmon Platinum in second position and EA Sports Active in third.
Wii Fit, which needs just two more No. 1s to equal the record of Eidos' Who Wants To Be a Millionaire, has slipped to fourth place.
Meanwhile, Ubisoft's My Fitness Coach has risen up the charts from No. 14 to No. 9, making it three fitness-based products in the Top 10.
Other new entries this week includes Capcom's Bionic Commando in 14th position, Ubisoft's The Mystery of the Mummy in 15th place, THQ's Big Family Games at No. 30 and Codemasters' Damnation, which sneaks in at No. 35.
The ELSPA GfK-ChartTrack All Formats Top 10 in full (for the week ending May 23rd):
1. UFC 2009: Undisputed (THQ)
2. Pokmon Platinum (Nintendo)
3. EA Sports Active (EA)
4. Wii Fit (Nintendo)
5. FIFA 2009 (EA)
6. X-Men Origins: Wolverine (Activision Blizzard)
7. Wii Play (Nintendo)
8. Mario Kart Wii (Nintendo)
9. My Fitness Coach (Ubisoft)
10. Call of Duty: World at War (Activision Blizzard)