Cryptic Studios' 360 and PC MMO Champions Online will be published by Take Two.
The publisher has signed up the international distribution rights to the game, which is due out early next year.
Champions will be Take Two's first MMO. Cryptic is best known for its work on the City of Heroes and City of Villains online games, made for NCsoft.
"2K Games is a terrific publishing partner for Champions Online," said John Needham, CEO of Cryptic.
"Cryptic is proud that Champions Online will be 2K's first MMO title and we look forward to working together towards a tremendous launch next year."