In the keynote, entitled 'Game 3.0: Developing and Creating for the Third Age of Video Games', Harrison will "explore the seemingly infinite entertainment, creative, and commercial opportunities presented by the massively connected communities of players and developers" according to materials released by event organsier CMP.
It adds: "He will enlighten attendees as to what 'always on' can mean for both the game development industry and consumer, as well as what some of the innovative products and services are that will help content developers define and shape the meaning of Game 3.0.
"The SCE Worldwide Studios head will also demonstrate some exclusive insights into the company's development of products and services that will help define future growth in the video game market."
GDC takes place from March 5th to 9th at the Moscone Convention Center in San Francisco. Harrison's keynote takes place on Wednesday, March 7th from 10.30am to 11.30am.
Earlier this week, CMP confirmed that Nintendo's Shigeru Miyamoto will be conducting a keynote the next day.
"Each console cycle gives platforms the chance to reinvent the experiences they enable developers to provide to gamers,” said Jamil Moledina, executive director of the GDC.
"Phil Harrison is uniquely positioned to apply both his prescient creative abilities and his command of a globe-spanning network of leading development teams - to bring the entire developer community in on the giant leap forward of the PlayStation 3"
More information on Game Developers Conference '07 can be found at the official site. The early bird deadline for registration is January 31st.