Nintendo has confirmed to Develop that developers can create Wii U and 3DS titles that will connect with rival platforms.
Earlier this week, UK developer Ripstone claimed that it was working on a title that would let Wii U owners play against smartphone users.
Now the platform holder has told Develop that not only is it possible to make cross-platform games, but that it is keen for studios to do so.
"We can confirm that cross-platform functionality is possible in certain titles that play on Nintendo 3DS and Wii U, as well as other video game systems not made by Nintendo," a spokesperson told Develop.
"We are committed to helping developers realise the full potential of their software on Nintendo systems."
Earlier this week, Microsoft's Phil Spencer hinted that cross-platform play may also be possible between Xbox One, PC and mobiles.
Additional reporting by Craig Chapple